Blarian

It shouldn't matter too much as far as getting CAST in a role... However, what happens is this, scenario: Vin Deisel auditons for a role as some skinny cracked out guy; he can get the role while he's still jacked but, they will make sure that he's actually willing to lose the weight for the role.

Same goes for skinny guys who want to play thugs, big football players whatever they have to beef up.

It will only hold you back as much as you let it. Just be willing to work on your body in a positive or negative way, whichever the role calls for. Otherwise, your role selection could be limited if you refuse to change your body... It all depends on what your "image" is, and that's why people like Vin Deisel don't lose 70 pounds and play some skinny choir boy.